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Article 69(8); Aug 2026

Review Article Other Virtual reality for managing pain and fear and anxiety during pediatric needle procedures: an umbrella review Thomas Saliba, Guillaume Fahrni Clin Exp Pediatr. 2026;69(8):609-621. Published online July 14, 2026

Meta-analyses suggest that virtual reality (VR) reduces self-reported pain, fear, and anxiety in children during needle procedures but has high heterogeneity, high overlap between primary studies, and low methodological quality, leading to a "very weak" GRADE (Grading of Recommendations Assessment, Development and Evaluation) classification. Clinicians should view VR as a promising additional distraction tool; however, VR cannot yet replace current analgesic and anxiolytic strategies. Future research should focus on age-stratified analyses, measurement tool standardization, and modern VR technology

DOI: https://doi.org/10.3345/cep.2026.01221

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Endocrinology Linking pediatric obesity to youth-onset type 2 diabetes: integrated longitudinal and cross-sectional evidence from population-based studies worldwide Ashraf T. Soliman, Fawzia Alyafei, Nada Alaaraj, Noor Hamed, Shayma Mohamed, Ahmed Elawwa Clin Exp Pediatr. 2026;69(8):622-635. Published online July 20, 2026

Pediatric obesity and youth-onset type 2 diabetes have increased simultaneously across 6 continents over the last 25 years. Approximately 75% of affected youths are obese at diagnosis, beta-cell declines occur rapidly, and microvascular complications occur early. Glucagon-like peptide-1 receptor agonists and bariatric surgery achieve meaningful weight loss and glycemic improvement; however, the primary prevention of childhood obesity remains the most powerful strategy for arresting this epidemic.

DOI: https://doi.org/10.3345/cep.2026.01228

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Editorial Neurology Network-based biomarkers in pediatric drug-resistant epilepsy Joseph Lim, Jaeso Cho, Hunmin Kim Clin Exp Pediatr. 2026;69(8):636-638. Published online July 24, 2026

Conventional preoperative evaluation in pediatric drug-resistant epilepsy relies on clinical surrogates that quantify seizure exposure but not its impact on brain networks. A newly developed diffusion-weighted imaging connectome biomarker, anchored to intracranial electroencephalography-confirmed seizure onset zones and resolved across 6 neurocognitive domains, addresses this gap. This individualized approach classifies cognitive impairment with high accuracy and may offer a more precise, clinically interpretable tool to inform surgical timing.

DOI: https://doi.org/10.3345/cep.2026.01774

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Original Article Other Association between sodium content of intravenous immunoglobulin and electrolyte changes and clinical course of Kawasaki disease Yoshitaka Watanabe, Naomi Yagi, Toya Hattori, Chisato Oyake, Shota Endo, Maria Yoshimi, Takayoshi Kyoda, Hirokazu Ikeda Clin Exp Pediatr. 2026;69(8):639-645. Published online July 1, 2026

Question: Hyponatremia in Kawasaki disease is associated with inflammation and disease severity. Intravenous immunoglobulin (IVIG) formulations feature various sodium contents. What is the clinical impact of such variations?
Finding: IVIG sodium content was associated with sodium, potassium, and protein level changes.
Meaning: Coronary outcomes were similar but electrolyte changes differed: high-sodium IVIG caused hypokalemia, whereas low-sodium IVIG caused hyponatremia. IVIG preparation requires consideration when interpreting laboratory values.

DOI: https://doi.org/10.3345/cep.2026.00619

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Gastroenterology Prognosis of pediatric hepatic Wilson disease with ATP7B loss of function variants Amresh Kumar Mishra, Moinak Sen Sarma, Anchal Dubey, Pratik Gadekar, Amita Moirangthem, Anshu Srivastava, Amrita Mathias Clin Exp Pediatr. 2026;69(8):646-654. Published online July 13, 2026

Question: Do the loss of function (LOF) of ATP7B mutated variants affect the severity or outcomes of hepatic Wilson disease (WD)?
Finding: LOF is associated with advanced liver disease, portal hypertension, and extrahepatic involvement. LOF did not determine hepatic or overall outcomes. ATP7B: c.813C>A (truncation variant) has an aggressive course with higher predisposition to acute liver failure. Lower serum exchangeable copper levels and higher disappearance of Kayser-Fleischer ring were observed in ATP7B: c.3809A>G (nontruncation variant) suggesting a better effect of chelation and lesser systemic copper.
Meaning: Truncation of the ATP7B protein determines the severity of the phenotype in WD.

DOI: https://doi.org/10.3345/cep.2026.00689

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Neonatology (Perinatology) Efficacy and safety of home-based fiberoptic blanket versus hospital-based light-emitting diode phototherapy for neonatal jaundice: a retrospective cohort study from Thailand Chayatat Ruangkit, Thanyathorn Thaninjeerawat, Saitarn Klaidangklum, Saowalak Prasopa, Pongsakorn Atiksawedparit, Sasivimon Soonsawad Clin Exp Pediatr. 2026;69(8):655-664. Published online July 1, 2026

Question: Is a home-based fiberoptic phototherapy blanket as effective and safe as hospital-based overhead light-emitting diode phototherapy for the treatment of neonatal jaundice?
Finding: Home phototherapy (HPT) resulted in a slower bilirubin reduction rate than inpatient phototherapy (IPT); however, both modalities achieved the therapeutic targets without phototherapy-related complications.
Meaning: With careful patient selection, structured monitoring, and reliable follow-up, HPT is a safe and feasible alternative to IPT for neonatal jaundice.

DOI: https://doi.org/10.3345/cep.2026.00703

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Neurology Patient-independent automated pediatric seizure monitoring based on expert-labeled electrographic ictal data as core reference knowledge Yoon Gi Chung, Jaeso Cho, Anna Cho, Hunmin Kim, Byung Chan Lim Clin Exp Pediatr. 2026;69(8):665-675. Published online July 14, 2026

Question: Can deep learning models trained on expert-verified electroencephalography segments reliably detect seizures and be applied to single-channel wearable monitoring?
Finding: This technique demonstrated 80.1%?100% sensitivity and low false-alarm rates. On 1,604 expert-labeled segments, the model outperformed previous studies in terms of latency and accuracy across unseen datasets.
Meaning: Expert-labeled data are essential for achieving universal seizure detection. This channel-specific approach enabled efficient and continuous monitoring using wearable devices.

DOI: https://doi.org/10.3345/cep.2026.01011

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Clinical Note Nephrology (Genitourinary) A rare genetically confirmed case of apparent mineralocorticoid excess syndrome due to a homozygous HSD11B2 variant in a 2-year-old child with severe hypertension: response to targeted therapy Bashair Alabbasi, Mugahid Elamin, Ghadah Alsallum, Ghada Alzahrany Clin Exp Pediatr. 2026;69(8):676-679. Published online July 24, 2026

DOI: https://doi.org/10.3345/cep.2026.01473

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Neonatology (Perinatology) Peters anomaly: a rare etiology of corneal clouding in the newborn Gregory Ison, Srividya Naganathan Clin Exp Pediatr. 2026;69(8):680-682. Published online July 13, 2026

DOI: https://doi.org/10.3345/cep.2026.00794

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Perspective Neonatology (Perinatology) Neonatal care in a low-birthrate society: insights from population-based observations in Japan Hirokazu Arai, Hiroshi Miura, Yohei Onodera, Hiroyuki Adachi, Akira Sato, Tomoo Ito, Masaru Mizuno Clin Exp Pediatr. 2026;69(8):683-685. Published online July 24, 2026

Declining birth rates are reshaping neonatal care. In low-birthrate settings, shifts in the underlying causes of neonatal death, including greater use of perinatal palliative care for trisomy 18 and challenges in maintaining expertise in extremely low-birth-weight infants, may contribute to fluctuations in neonatal mortality. These observations highlight the need for a coordinated system-level support.

DOI: https://doi.org/10.3345/cep.2026.01095

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TOPICS

Adolescence Medicine
Allergy
Cardiology
Critical Care Medicine
Developmental and Behavioral Medicine
Emergency Medicine
Endocrinology
Gastroenterology
General Pediatrics
Genetics and Metabolism
Hematology

Browse all articles >

Infection
Neonatology (Perinatology)
Nephrology (Genitourinary)
Neurology
Nutrition
Oncology
Neurobehavior
Pulmonology
Rheumatology
Other

ARTICLE CATEGORY

Perspective
Review article
Systematic review and meta-analysis
Editorial
Present Perspective on the Past Research
Original article
Letter to the editor
Clinical note
Case report
Others

Browse all articles >

BROWSE ARTICLES

Current issue
All issues
Accepted articles
Ahead-of print
Most viewed
Most downloaded
Most cited
Funded articles
Search
Author index

FOR CONTRIBUTORS

Instructions for authors
Research and publication ethics
Instructions for peer reviewers
Author?s checklist
Best article award
Best reviewer award
E-submission
Copyright transfer agreement

ABOUT

Aims and scope
About the journal
Editorial board
Best practice
Open access
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Contact us

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